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Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

简要描述:Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody
宿主: Polyclonal, Rabbit,IgG
反应性: Human;Rat;Mouse;
应用: IF;WB;IHC;ELISA

产品型号: YP-Ab-17668

所属分类:多克隆抗体

更新时间:2024-10-31

详细说明:

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody

抗体,也叫免疫球蛋白(Ig),是一种能特异性结合抗原的糖蛋白,而抗原是在易感染动物体内引发抗体产生的物质。在体内,抗体是由于外源性分子的侵袭而产生的。抗体以一个或者多个Y字形单体存在,每个Y字形单体由4条多肽链组成,包含两条相同的重链和两条相同的轻链。轻链和重链是根据它们的分子量大小来命名的。Y字形结构的顶端是可变区,为抗原结合部位。任何一个抗体的轻链都可以分为κ或λ型(基于小分子多肽结构上的差异),每一个抗体的重链则决定了它的类或型。






保存温度:-20℃

产品详情

Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p10 protein resulting from cleavage adjacent to D330.

免疫原详细信息

The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:281-330

相关试剂

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants


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备注:图片仅供参考。仅供科研,不可用于临床。




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