TRAIL Polyclonal Antibody
简要描述：TRAIL Polyclonal Antibody宿主: Polyclonal, Rabbit,IgG反应性: Human;Rat;Mouse;应用: WB;IHC;IF;ELISA
产品型号： YP-Ab-00578
所属分类：多克隆抗体
更新时间：2024-10-31
详细说明：
TRAIL Polyclonal Antibody
抗体，也叫免疫球蛋白（Ig），是一种能特异性结合抗原的糖蛋白，而抗原是在易感染动物体内引发抗体产生的物质。在体内，抗体是由于外源性分子的侵袭而产生的。抗体以一个或者多个Y字形单体存在，每个Y字形单体由4条多肽链组成，包含两条相同的重链和两条相同的轻链。轻链和重链是根据它们的分子量大小来命名的。Y字形结构的顶端是可变区，为抗原结合部位。任何一个抗体的轻链都可以分为κ或λ型（基于小分子多肽结构上的差异），每一个抗体的重链则决定了它的类或型。
产品详情
TRAIL Polyclonal Antibody detects endogenous levels of TRAIL protein.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF10. AA range:31-80
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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备注：图片仅供参考。仅供科研，不可用于临床。
