Lamin A/C mouse mAb
简要描述：Lamin A/C mouse mAb宿主: Monoclonal, Mouse反应性: Human应用: WB;IF
产品型号： YP-Ab-00104
所属分类：单克隆抗体
更新时间：2024-11-01
详细说明：
Lamin A/C mouse mAb
抗体，也叫免疫球蛋白（Ig），是一种能特异性结合抗原的糖蛋白，而抗原是在易感染动物体内引发抗体产生的物质。在体内，抗体是由于外源性分子的侵袭而产生的。抗体以一个或者多个Y字形单体存在，每个Y字形单体由4条多肽链组成，包含两条相同的重链和两条相同的轻链。轻链和重链是根据它们的分子量大小来命名的。Y字形结构的顶端是可变区，为抗原结合部位。任何一个抗体的轻链都可以分为κ或λ型（基于小分子多肽结构上的差异），每一个抗体的重链则决定了它的类或型。
产品详情
This antibody detects endogenous levels of Lamin A/C and does not cross-react with related proteins.
免疫原详细信息
Purified recombinant human LMNA protein fragments expressed in E.coli.
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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备注：图片仅供参考。仅供科研，不可用于临床。
